PC Software for quantization of synergism and antagonism and determination of IC50, ED50 and LD50. CompuSyn for Drug Combinations and for General Dose-Effect Analysis. Mixture-Algebraic estimate analysis with CalcuSyn software shows the combination index (CI) values when combination of different concentrations was used in. (Based on the cited article of Chou, T-C and Talalay, P Analysis of combined drug effects: A new look at a very old problem. CalcuSyn for Windows, Multiple-drug dose-effect analyzer and manual. In floppy disk.(cited 181 times) No longer in use due to changes in computer hardware/software.
#Calcusyn manual#
Manual and Software, Biosoft, Cambridge, U.K., 1987. Dose-effect analysis with microcomputers: Quantitation of ED50, LD50, synergism, antagonism, low-dose risk, receptor-ligand binding and enzyme kinetics. The interface is friendly to all users, the response time is good and the computer’s performance is not going to be hindered at all.KEY REFERENCES FOR DOSE-EFFECT ANALYSIS FROM CHOU ET AL Computer Software In conclusion, CalcuSyn is an efficient piece of software which can help people in creating new mixed drug treatment and more effective ones.
Experiment details such as title, date, investigator and other notes you deem necessary can be easily provided in a separate pane.īased on a number of user-selected drugs, you can easily create a summary graph, so that you can better view information about your mixed drug treatment experiment. You can add drugs to CalcuSyn manually or with the help of a wizard, so that you can be sure you do not forget to include certain information. Nonetheless, it goes without saying that you still require some specialized knowledge in order to get around CalcuSyn.įirst and foremost, you should know it is possible to import data from TXT and XLS files, as well as export it to such documents, so that you can use it in other programs or keep it safe. The installation process is over in a jiffy, while the interface you come by encompasses a menu bar, a few buttons, and two panes in which to display a folder structure and selected information.Įxtensive Help contents are provided and thus, it becomes obvious that both power and novice users can find their way around it, without facing any kind of difficulties. It can make multiple calculations using the Median Effect methods. ( c ) NCI-H460 and A549 cells were exposed to 10 M DT-13 and/or 0.01 M NVB for 12 h, and incubated for another 8 days.
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